We analyzed more than 300 biomarkers in two multicenter, observational clinical trials including more than 1,200 patients across 37 sites, many of whom experienced sepsis, shock, major surgery and trauma.4 Two biomarkers stood out for assessing the risk of acute kidney injury development: TIMP-2 and IGFBP-7.
When can AKI intervention begin?
The NephroCheck® Test and AKIRisk® Score can help Dr. Harold Szerlip decide when to intervene earlier with patients at risk of developing acute kidney injury in order to try to prevent progression to kidney damage.
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The two biomarkers are involved in responses to a wide variety of tissue insults (inflammation, oxidative stress, ultraviolet radiation, drugs and toxins),5-7 and each is thought to be involved in G1 cell-cycle arrest during the earliest phases of injury to the kidney.4
TIMP-2 (Tissue Inhibitor of Metalloproteinase-2)8
IGFBP-7 (Insulin-like Growth Factor Binding Protein-7)9
TIMP-2 (Tissue Inhibitor of Metalloproteinase-2)8
The two biomarkers are involved in responses to a wide variety of tissue insults (inflammation, oxidative stress, ultraviolet radiation, drugs and toxins),5-7 and each is thought to be involved in G1 cell-cycle arrest during the earliest phases of injury to the kidney.4
- Soluble protein expressed in kidney and other tissues10
- Binds to and inhibits the activity of various metalloproteinases (MMPs)11
- Believed to be involved or induced in several processes associated with leukocyte infiltration, cellular injury and disruption of cell contacts12-17
- Implicated in G1 cell-cycle arrest4
IGFBP-7 (Insulin-like Growth Factor Binding Protein-7)9
The two biomarkers are involved in responses to a wide variety of tissue insults (inflammation, oxidative stress, ultraviolet radiation, drugs and toxins),5-7 and each is thought to be involved in G1 cell-cycle arrest during the earliest phases of injury to the kidney.4
- Soluble protein expressed in kidney and other tissues18
- Believed to be involved or induced in several types of processes associated with cellular injury19-25
- Implicated in G1 cell-cycle arrest4
NephroCheck® AKIRisk® Score: A Renal “Alarm System”
The NephroCheck® Test measures TIMP-2 and IGFBP-7 in urine,
providing a single quantitative result in about 20 minutes.
